Ocular involvement in acute lymphoblastic leukaemia.

Investigation of TEL/AML1 and BCR/ABL Fusion Genes in Patients Affected by Acute Lymphoblastic Leukaemia Using Interphase in situ Hybridization

Gene variants of CYP1A1 and CYP2D6 and the risk of childhood acute lymphoblastic leukaemia; outcome of a case control study from Kashmir, India

Studies on associations of various polymorphisms in xenobiotic metabolizing genes with different cancers including acute lymphoblastic leukaemia (ALL) are mixed and inconclusive. The current study analyzed the relationship between polymorphisms of phase I xenobiotic metabolizing enzymes, cytochromes P450 1A1 (CYP1A1) and CYP2D6 and childhood ALL in Kashmir, India. We recruited 200 confirmed ALL...

An Unusual Site of Acute Lymphoblastic Leukaemia Relapse: Challenge for Gynaecologists.

Secondary involvement of female genitourinary system [1, 2] is more common in lymphoma than leukaemia [3, 4]. In leukaemia, acute myeloid leukaemia (AML) is known to have extra medullary involvement (chloroma, granulocytic sarcoma, etc.) [5, 6]. In case of acute lymphoblastic leukaemia (ALL), except for CNS and testis other extra medullary sites are rarely involved [7, 8]. Amongst genitourinary...

Iris involvement in leukaemia.

Involvement of the eye and the adnexa in leukaemia is not uncommon, and one half of patients can expect involvement at some stage of the disorder. The literature contains numerous reports of these conditions and a wide range ofocular structures may be affected, but iris involvement is relatively rare. Allan and Straatsma (i 96 I) found two cases out of 76 with eye involvement studied pathologic...

Face Bones Involvement and Relapse in a Case of Childhood Acute Leukemia

Midface bones are an unusual site for primary presentation and relapse in acute lymphoblastic leukemia. Herein, we describe a case of acute pre B cell lymphoblastic leukemia with leukemic infiltration of maxilla and bone marrow involvement. At the time of relapse, the patient presented again with maxilla involvement and the phenotype changed to biphenotypic lymphoblastic leukemia. Our case sug...